About "Development of Radiation Therapy and Diagnostic Techniques"

 

　Profile #31: Dr. YASUI Hironobu, Associate Professor

　Laboratory of Radiation Biology,

　Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine

 

　【Research Topics】

　・Research and development of new therapeutic technology using radiation

　・Analysis of radiation response by imaging technique

　

 

 

  ～Aiming to contribute to medical care through visualization of radiation science～ 

 

 The word "radiation" gives us a scary image of something invisible being unknowingly exposed to us, so people generally want as little to do with it as possible, even considering its medical benefits in cancer treatment and diagnostic imaging.

 However, in recent years, the development of radiation technology has been remarkable, especially in human medicine. Regarding cancer treatment, high-energy X-rays and particle beam therapy have started clinically, mainly due to advances in engineering and physics. In terms of diagnosis of diseases, PET/SPECT diagnosis, which can obtain functional image information with high sensitivity using various nuclear medicine diagnostic agents, has been introduced to clinic in addition to X-ray and CT. Both are still in their infancy in the veterinary field, but in order for these advanced technologies to become common medical care, it is essential to accumulate evidence in basic biology using cells and experimental animals. Furthermore, visualization by imaging technology is also important to remove the anxiety caused by invisibleness of the effects of radiation.

 By performing image analysis and quantitative analysis of biological responses to radiation using imaging, cell biology, and molecular biology techniques, we aim to provide more efficient therapeutic effects and diagnostic prediction effects based on evidence, developing diagnostic techniques. Recently, focusing on cell senescence and cell death associated with micro-metals, we are working on the development of new therapeutic techniques such as senescence-targeted and iron/copper-dependent cell death-targeted therapies combined with radiation.

 

Radiation effects on nuclear morphology and cytoskeleton (multiple fluorescence staining)

 

Changes in oxygen environment of transplanted tumors after X-irradiation (PET hypoxic imaging)

 

International culture exchange with a SaSSOH2019 invitee（RWC2019）