About “Inflammatory colorectal polyps in Miniature dachshunds”

 

　Profile #2: Dr. OHTA Hiroshi, Lecturer

　Laboratory of Veterinary Internal Medicine, 

　Department of Clinical Sciences, Faculty of Veterinary Medicine

 

 

 

 

 

 

 

～Inflammatory colorectal polyps in Miniature dachshunds～

 

 Inflammatory colorectal polyps (ICRPs) in Miniature dachshunds are characterized by the formation of multiple inflammatory polyps in the colorectal area and are thought to be a breed specific canine inflammatory bowel disease in Japan. We previously reported that T helper cell cytokines, such as interleukin-17, and chemokines are upregulated in polyp lesions of dogs with ICRPs. Now, we try to identify the causative single nucleotide polymorphism for ICRPs using whole-exome sequencing analysis.