2026年 10月 Student Monthly Progress を開催しました

10月29日 (木)にStudent Monthly Progressが開催されました。5名の大学院生が研究内容について発表しました。

 

【Presenters】

1. INOUE Maho: Laboratory of Infectious Diseases

<Effects of Antibiotics and Probiotics on Vaccine Immune Responses in Calves>

 

2. ITOI Takito:Laboratory of Biochemistry

<High-Resolution Framework for Tracking Seasonal Adaptation and Hibernation Onset in Syrian Hamsters>

 

3. DE SOUSA MORAES Cassia Nazare: Division of Biological Response Analysis

<Antiviral Efficacy of Favipiravir and Pathogenesis Mitigation in a Syrian Hamster Model of Oropouche Virus Infection>

 

4. GUO Zixuan: Division of Risk Analysis and Management

<Therapeutic Evaluation of T-705 Alone and in Combination with Monoclonal Antibodies for Feline SFTS>

 

5. YUNUS Muhammad: Division of Bioresources

<Rapid and Simple Detection of Mycobacterium tuberculosis and Fluoroquinolone Resistance Using LAMP and Dipstick DNA Chromatography>

 

 【Chairs】

CHIMALIRO Laston Frank: Laboratory of Parasitology

FUJII Eri: Division of Molecular Pathobiology

 

 

 

 

 ❖座長レポート❖ 

 

《Effects of Antibiotics and Probiotics on Vaccine Immune Responses in Calves》

INOUE Maho

 

This study investigated the potential influence of gut microbiota modulation on vaccine-induced immune responses in calves. Preliminary observations indicated that individual administration of either an antibiotic regimen or a probiotic strain (Clostridium butyricum) modified vaccine performance. Intriguingly, concurrent administration of both agents appeared to modulate immune responses differently than single treatments. These findings suggest an interplay between antimicrobial administration and probiotic supplementation during vaccination. Ongoing gut microbiota profiling aims to clarify the potential mechanisms involved and support the refinement of livestock immunization strategies.

 

《High-Resolution Framework for Tracking Seasonal Adaptation and Hibernation Onset in Syrian Hamsters》

 ITOI Takito

 

This study established a daily-resolution monitoring framework to analyze physiological and endocrine transitions associated with hibernation onset in Syrian hamsters (Mesocricetus auratus). Combining continuous body temperature logging with frequent non-invasive monitoring and blood sampling enabled detailed observation of weight dynamics and feeding behavior prior to hibernation. The framework facilitated sample collection immediately following hibernation onset, allowing preliminary tracking of plasma hormone profiles. This platform offers a methodology for longitudinal endocrine studies investigating seasonal metabolic regulation.

 

 《Antiviral Efficacy of Favipiravir and Pathogenesis Mitigation in a Syrian Hamster Model of Oropouche Virus Infection》

DE SOUSA MORAES Cassia Nazare

 

This study evaluated candidate antiviral interventions against Oropouche virus (OROV) using an established Syrian hamster infection model. Treatment with favipiravir demonstrated protective efficacy and was associated with reduced viral presence in peripheral organs and neural tissues, including under delayed dosing conditions. Comparative transcriptomic profiling suggested that effective viral suppression helped attenuate infection-associated inflammatory and metabolic gene dysregulation. These preliminary results highlight favipiravir as a potential therapeutic candidate and provide insights into host-pathogen interactions during OROV infection.

 

《Therapeutic Evaluation of T-705 Alone and in Combination with Monoclonal Antibodies for Feline SFTS》

GUO Zixuan

 

This study explored potential therapeutic strategies for feline severe fever with thrombocytopenia syndrome (SFTS). Following preliminary screening in relevant cell lines and immunocompromised mouse models, antiviral regimens involving T-705 (favipiravir) alone and in combination with specific monoclonal antibodies were assessed in an experimental feline model. Animals receiving the combination treatment showed favorable trends in viral load reduction and recovery of physiological parameters compared to monotherapy. These observations provide baseline data for further refining antiviral strategies against feline SFTSV infection.

 

《Rapid and Simple Detection of Mycobacterium tuberculosis and Fluoroquinolone Resistance Using LAMP and Dipstick DNA Chromatography》

YUNUS Muhammad

 

This study describes the preliminary development of an isothermal assay combining loop-mediated isothermal amplification (LAMP) with dipstick DNA chromatography for the detection of Mycobacterium tuberculosis (MTB) and key gyrA mutations conferring fluoroquinolone resistance. Initial evaluations demonstrated analytical sensitivity and specificity without apparent cross-reactivity against non-target respiratory pathogens. The combined assay differentiated wild-type and mutant sequences across reference models and clinical isolates within a single operational step, suggesting its potential utility for point-of-care diagnostics in resource-limited settings.